Philosophy Trinity Essay Example for Free

Philosophy Trinity Essay Many philosophers have addressed and questioned the subject regarding the unity and trinity of God. Yahya Ibn Adi was a philosopher and a Monophysite scholar of the Arab Classical Period who has firmly given treatises of his own interpretation on this subject. This has caused manygfjkfgmngcccccccccccccccccccccccccccccccccccb scholars and other philosophers to critique his understandings and express their own viewpoints of Yahyah Ibn Adi’s philosophy on the unity and trinity of God. Emilio Platti in his article Yahya B. Adi And His Refutation Of Al-Warraq’s Treatise On The Trinity In Relation To His Other Works and Sidney H. Griffith in her article Commending Virtue And A Humane Polity In 10th Century Baghdad The Vision of Yahya Ibn Adi are two scholars who explored Yahya’s refutations. In their articles they discuss b a good indication to what Yahya’s belief was on the subject of unity of God. Many philosophers challenged his standpoints on the unity as well as the trinity resulting in Yahya to refute the situation. Two philosophers in particular who attributed Yahya’s treatises were Al-Kindi and and Al-Warraq. One of Al-Kindi’s reasoning for attributing Yahya’s treatise on the unity and trinity of vb the unity of God. Griffith explains how Yahya firmly asserts that â€Å" God is said to be ‘one’ in number in reference to his ‘substance, while in reference to his ‘quiddity’ or whatness’, which, according to Yahya, is essentially described as being ‘generous/good, ‘wise’, and ‘powereful’, he is ‘three’†4 In comparison with Griffith’s article, Emilio Pratti critiques how Yahya refutes to Al-Kindi’s attribution on treatise on the unity. Pratti believed that â€Å"To al Kindi, he underlies that the Christians say on the one hand, that the Creator is one, and that his quiddity is one, but they also say, on the other hand, that He is three, as far as He is good, wise and powerful.. †5 Pratti stresses that this is not a contradiction because we can use â€Å"one† in the sense of one in subject and many in definition. In Pratti’s conclusion, he raises the questions â€Å"b in different ways, based on what the Scriptures are saying to them? Why should God not be present in a human being, as we understand it from the Gospels? † Pratti closes his argument insisting that there is no indication that this would be impossible, he believes there are many indications that God can certainly expose himself as such Emilio Platti’s argued that when it came to Yahya’s refutations, he found his ideas to be offered in an unorganized and sometimes contradictory way. Platti also scolds how certain arguments by Yahya Ibn Adi’s may be given in a particular reply. In regards to how Yahya Ibn Adi responds to those who challenge his treatise, Pratti states that â€Å"†¦most of his apologetical works are written in the form of a rebuttal; he quotes, most probably in extensor, an already existing refutation of the Christians by a Muslim-or a refutation of the Jacobites by a Nesotrian – and replies paragraph by paragraph† (173) Pratti argues that this way of responding has several consequences. vcghaks about how Yahya replies to the philosopher Al-Kindi’s treatise on the unity. To al Kindi, he underlies that the Christians say on the one hand, that the Creator is one, and that his quiddity is one, but they also say, on the other hand, that He is three, as far as He is good, wise and powerful†¦.. Pratti asserts that this is not a contradiction for we Pratti raises the questions â€Å"Why should God not reveal Himself under the three aspects of his hypostases, designated by the Christians in different ways, based on what the Scriptures are saying to them? Why should God not be present in a human being, as we understand it from the Gospels? † Pratti concludes that there is no indication that this would be impossible, he believes there are many indications that God can certainly expose himself as such. Sidney H. Griffith discusses how Yahya refutes back to Al-Kindi†¦Griffith says â€Å"yahya ibn adi’s habit of quoting large portions of the texts of those with whose ideas he disagrees in his refutations of them that a significant portion of the lost work of an important comparative religionist in the early Islamic period, Abu Isa al-Warraq has survived, allowing a modern editor to bring out an edition of what he considers to be the major part of Abu Isa’s anti-Christian work. Griffith describes Yahya Ibn Adi’s unity of God to be.. Griffith describes how Yahyah Ibn Adi wrote a handful of apologetic texts of his own in the Kalam style defending the doctrine of Trinity. Griffith describes . yahya argues Al-Kindi challenged Yahyah Ibn Adi’s treatise as well. Yahya’s rebuttle was that â€Å"given the Muslim philosopher’s own description of God as simultaneously God as ‘one’ and as ‘substance, al-Kindi too faced a logical conundrum involving the notions of ‘one and ‘three’. †(89) Yahya further claims that Al-Kindi misused technical terms When it came to Yahya’s discussion of the Christian doctrinal formulae, he found that Al-Kindi misinterpreted and misused technical terms that were comprised in it. Yahya also clarifies that God is said to be ‘one’ in number in reference to his ‘substance’. Griffith goes forth to say that Yahya goes to considerable lengths to dispose of what he considers to be logically faulty definitions of the ‘one’. Yahya describes God of having three attributes which are goodness/generosity, wisdom, and power. When Yahya responds to other philosophers challenging his treatise, he speaks of the three divine attributes One philosopher in particular who challenged Yahya’s philosophy on the unity and trinity of God was al-Kindi. Al-Kindi’s reasoning for this was that he wanted to â€Å"challenge Christians for the unreasonableness of their al-talit on the foundation of â€Å"logic and philosophy, and more specifically on the grounds that their Trinitarian confession necessarlily involved the repulsive idea of introducing â€Å"composition (al-tarkib) into the God head† To sum up Al-Kindi’s response, he believed that the God, Jesus, and the Holy Spirit were not eternal. Griffith then describes Yahya’s reaction to this by stating that â€Å"Yahya argues that given the Muslim philosopher’s own description of God as simultaneously God as ‘one’ and as ‘substance’, al –Kindi too faced a logical conundrum involving the notions of ‘one and three. ;† Griffith also affirms that Yahya further found that al-Kindi misinterpreted and misused technical terms that were comprised in his argument about the unity of God. Griffith explains that Yahya asserts that â€Å" God is said to be ‘one’ in number in reference to his ‘substance, while in reference to his ‘quiddity’ or whatness’, which, according to Yahya, is essentially described as being ‘generous/good, ‘wise’, and ‘powereful’, he is ‘three’† This paper will demonstrate how two critics have formed and expressed their own understandings of Yahya’s treatise on unity and trinity of God. How yahya responds to other scholars attributes on his treatise. Many philosophers challenged Yahya Ibn Adi on his treatise on the unity and trinity of God. In Emilio Platti’s article, he critques how Yahya refutes to others about their attributions to his own works. This paper will demonstrate how two critics have formed and expressed their own understandings of Yahya’s treatise on unity and trinity of God. How yahya responds to other scholars attributes on his treatise. Many philosophers challenged Yahya Ibn Adi on his treatise on the unity and trinity of God. In Emilio Platti’s article, he critques how Yahya refutes to others about their attributions to his own works. In conclusion, it is evident that there are many ways to interpret Yahya Ibn Adi’s treatises on the unity and trinity of God. There are also numerous ways one can interpret how Yahya refuted back to his own critiques. Griffith and Pratti are two critics who certainly had similar interpretations of Yahya’s refutations.

Monsters We Have Created Essay Example for Free

Monsters We Have Created Essay Fetal tissue implantation/therapy has many uses such as placing fetal brain tissue into a person with Parkinson’s disease, and the fetal tissue will supply chemicals lacking in the diseased brain. These two things are related by abortion. In order to receive fetal tissue a woman must have an abortion or a miscarriage, and if a baby doesn’t have the desired characteristics and traits when prenatal testing is done the parents can choose to have an abortion. Prenatal testing does have its pros and is not completely bad. Prenatal testing can be used to detect diseases or syndromes in your unborn child, can detect stillbirth, they enable medical or surgical treatment before or after birth, and it can determine the sex of your baby which is the most anticipated event while pregnant with the exception of the actual delivery of the baby. There are invasive and non-invasive methods of prenatal testing. Invasive methods include intruding into the mother’s body, or even probing inside the embryo. Some non-invasive methods include various forms of sonography which is the use of acoustic discharge measurements, as well as the serological examination which includes sampling the blood of the mother. Non-invasive prenatal testing are said to have a very low chances of side-effects. In retrospect of non-invasive methods, invasive methods produce actual results while non-invasive give guesses or general diagnoses. Fetal tissue implantation/therapy has its benefits also. Fetal tissue implanting is said to treat diseases such as Parkinson’s disease, Alzheimer’s, and Huntington’s disease. Fetal tissue implantation/therapy has also been reported as partially curing paralysis. Fetal tissue contains high doses of dopamine, and can help produce dopamine in person who doesn’t have the ability to produce dopamine on their own, or they aren’t able to produce enough dopamine. Dopamine is a neurotransmitter. It is one of the chemicals that is responsible for transmitting signals in between the nerve cells and the brain. So for someone who doesn’t have that ability fetal tissue implantation could in a sense save their life. Prenatal testing has just as many cons as it has pros. Nothing can ever be 100% good. Incorrect diagnoses are the biggest con. Incorrect diagnoses can lead to a downward spiral of cons like abortions. The pressure to abort is the 2nd biggest con. The reason why is because if a child isn’t â€Å"perfect† some parents, even doctors feel as though it’s best to terminate the pregnancy and try again. The bad thing about that is you never know what you’re going to get. You could continue to have babies with disabilities, and in the end you have literally wasted several lives. When people abort babies because of a possible disability shows a lack of sympathy for the disabled which is in itself a con. Another con that coincides with disabled children is that there aren’t many support groups for parents with disabled children. There is also the pressure of life and death decisions. No parent wishes for a disabled child, and when faced with the fact that they could possibly have one they play the life or death card and are forced to choose which decision to make. There are cons of fetal implantation/therapy also. The major one is that you are â€Å"messing with human life†. Most people believe that when it comes to children or life in general you should take what you get because life is a very precious thing. Some believe that probing around in an embryo and playing something like a guess and check is immoral and shouldn’t be done. Religious people believe that when you use fetal implantation/therapy is in a sense â€Å"playing† with God. They too believe that God has given you what he desired to give you and you should take it and love your child regardless. Cloning humans also falls into a con of fetal testing/implantation/therapy. It is said that scientists are trying to create the â€Å"perfect† human, but there is no such thing, because what’s perfect to one person may not be the same perfect as someone else. So you can never completely achieve a â€Å"perfect† human being. In conclusion, both prenatal testing and fetal implantation/therapy have equally the number of pros and cons. Both have the ability to be beneficial but they can also become monsters if used beyond their means. Nothing can be 100% good or bad. Anything in this world that is created by man has the ability to be a monster. Everything also has the ability to be something good. Whether something is good or bad depends on how humans choose to use them. Works Cited Fetal Tissue Implant.   Infoplease.

The Use Of Innovation At Pizza Hut Commerce Essay

The Use Of Innovation At Pizza Hut Commerce Essay The pizza hut has rivals like domino pizza, papa john and gogo pizza always the rival of pizza hut try to make or introduce new pizza or new food to attract the customers. But pizza hut management is thinking some think new which could be innovation but technological, which can reduce the staff, time and cost of the organization as well as which can provide good and efficient services and also attract the customers, so after the consideration the pizza hut technology management innovate the mobile text ordering, mobile portable card payment machines and online ordering such kinds of devices are the innovation as well as the new technology for the pizza hut. The pizza hut is 1st organization who introduce this innovation in the form of technology introduce in the pizza chain restaurant. So we can say that it is a technology but innovation for the pizza hut as well as in the pizza chain restaurant. Innovation:- Innovation is not a single action but a total process of interrelated sub-processes. Is not just the conception of a new idea, not the invention of a new device, nor the development of a new market. the prcess is all these things acting in an integrated fashion.(Myers Marquis, 1969) All activities which is involved in the procedure of generating ideas, development of technology marketing and producing new products and the process of manufacturing is called innovation (Trott, 2005) The innovation approach adopted by the management:- The organization benefits through innovation How the innovation improved the overall organization performance Estimate the successful of the innovation (Questionnaires from the customers) Conclusion and Recommendation Organization:- In the restaurant chain pizza hut is the world biggest pizza delivery organization as well as it is no.1 in the restaurant of pizza chain. The branches of pizza hut all over the world is 1300 out of 100 are outside the country. This organization has variety of pizza like flagship pan pizza as well as Sicilian, hand tossed and stuffed crust. The pizza hut expertise is to deliver fresh and hot pizza won the many awards as well as the loyalty of the million customers who loves the pizza. Pizza hut Mission Statement:- Mission statement is very important for every organization rather small or large, because a mission statement sets the general goals or purpose of the organization. It is very vital for the employees to obtain the organization goals. The Pizza hut mission statement is We make pride in making the perfect pizza and providing a courteous and helpful service on the time all the time. Every customer says, I will be back. We are the employer of choice offering team members opportunities for growth , Advancement, And Rewarding Careers in a Fun, Safe Working Environment. P.E.A.R.L.S PASSION for excellence in doing everything EXECUTE with positive energy and urgency. ACCOUNT-ABLE for growth in customer satisfaction and profitability. RECOGNIZE the achievement of others and have fun doing it. LISTEN and more importantly, respond to the voice of the customer. ,, There purpose is to add value for the customers to serve them by designing their store in a modern way, hiring the local community, respecting the environment, appreciating the team members, taking skills in to colleges and schools and supporting local organizations worldwide, to provide the unbeatable service to the customers. Pizza hut has very high quality of technology for online ordering for the great customer service of their customers. (Source: pizzahuthawaii.com) If anyone write Pizza hut in the search box of the Google instantly the company possible detail come up like offers, Bog of deals, Voucher, coupons, regular deals, pizza hut codes etc. The new and old customers can easily choose the field of her/his choice and get all the relevant information as well as if any one write Pizza hut in the search box of the Google it shows many links of the company to select from which we can be seen in the second picture. Source: Google.com The website of the company gives you very easy way to order online, location of the nearest store, food guide, feedback system, participating events, memberships, business information etc. The given below websites picture is describing that how Pizza hut is facilitating to their customers. For example if any customer enter the post code on the website he/she can easily track the nearest store, store phone number, store address as well as get information about the special offers, regular etc. Secondly while using the mobile phone the customer can easily give order by sending the text message to the pizza hut. This text message automatically will go to the nearest local store and they will deliver the pizza very quickly at the customer home. The customer can easily online register with the pizza hut as well. Order online Please enter you postcode, town or hut name below: Please enter your postcode, town or hut name below: Source: pizzahut.ca/ The Estimation/Evaluation:- Time by time Pizza hut considers the many things to check its improvement/progress. Increasing in number of customers (weekly, monthly and yearly) What are the customers views/suggestion/reviews regarding services and food Customers can give feedback thorough online as well as direct regarding their services etc The weekly average sale in a certain period. Change model:- Beckhard and Levin in 1969 and 1951 respectively developed the most famous change models. However other important contributions have been introduced by Quinn 1980 and Lewin 1980. Lewin:- The introductory methods for managing change are as follows according Lewin 1951. Unfreezing, existing behaviour and attitudes are supported by changing the present state equilibrium. According to new information new responses can be developed. Refreezing, by introduction of new responses in to personality concern can stabilize change. Field force analysis is a methodology for analysing change suggested by lewin which involves Transition to the future state is affected by analysing driving or restraining forces Differentiating between driving and restraining forces is essential. Action should be taking to increase critical driving forces and decrease critical restraining forces (Martin, 2006) Value change analysis can be applied to an organization , every time cost is reduce value substitution should be implemented, through this organization and customers both gain this has been practiced by Pizza hut self service check outs have not only reduce the staff cost but it also has made shopping experience easier for the consumer. (Horovitz, 2004) Guideline for Change Management:- Armstrong has explained the following factors to make sure that change management is successfully implemented in an organization. Understanding of the organizational structure and levels of change needs to be affective with the help of a strong and visionary leadership. Appropriate attitude and leadership is required to those concerned at all levels when implementing change strategies. Encourage workers who accept the idea of change participation in planning and implementation. Change should be advocated with the help of hard evidence and data. Instead of attitudes or corporate culture change should be implemented by process and behaviours. This should be completed by awarding people who encourage change and challenges. (Armstrong, 2006) Trigger: There are two types of trigger are involved in this change Internal Trigger: The management of Pizza hut realized that the sale and services are going bad due to negligence of staff and the shortage of staff so they need to change something, after the consideration they recognized the technology which can provide better customer services. External Trigger: Every organization is brining change introducing different technologies so Pizza hut also needs to bring the change in the organization and change could be innovation and innovation could be technology, however Pizza hut adapted the computer technology to satisfy the customers. Innovation Analysis:- Like many others companies Pizza hut is also affected in every season as well as environment and lots of staff mistakes. Pizza hut needs are to introduce a technology that can expand its way, and Pizza hut swap the workforce in to the computer technology. The Pizza hut management considered that our services are going to low level due to lack of staff, however empty spaces could be filled with the help of computer technology as well as efficient performance. The world is changed due to the new development in science since last decades. Computer technology is very good as well as very affordable. Pizza hut can easily use the technology and new improvement in technology is very important trigger for the Pizza hut, from last 10 years the information system is more advance and fast. The customers behaviour has been changed due to the computers. So mobile text ordering, mobile portable card payment machines and online ordering are the innovation for the pizza hut but these are the part of the technology which Pizza hut is using very efficiently. Benefits of Innovation:- Pizza hut is one of the biggest pizza restaurant in Britain, so Pizza hut needs an innovation and innovation could be a technology which can reduce the cost of staff and increase its profit as well as compete its rivals like dominos pizza, gogo pizza and papa johns. There are many benefits for the Pizza hut after introducing the technology which we discussed above mobile text ordering, mobile portable card payment machines. The customers can give order very easily at home through online as well as through text message which is very good for Pizza hut to increase its customers as well as sale and reduce the cost of staff, customers can order online at any time and day. This technology is very important or bon of Pizza hut. Pizza hut is the first organization whom introduced this facility, mobile text ordering, mobile portable card payment machines and online ordering are also very vital for Pizza hut because with the help of this technology Pizza hut is saving the time and money as we ll as reducing the staff and also giving better facility to their customers. Adapting this technology is one of the huge changes in the organization. By using good technology Pizza hut needs to handle the customer demands. Primary Research:- In order to understand the role of manager in the innovation, we took an interview one of the Pizza hut store manager. In an interview the store manager of Pizza hut described the basic role of the manager when any change or innovation adapted the Pizza hut as well he also described the factors while adapting the new technology, which are as given below. Understanding the innovation:- In an interview the store manager said that the manager always ensure that the innovation should be in new technology and understandable as well as supportable for the management and the staff as well as its also very helpful to achieve some benefits from the head office. Staff training:- The basic role of the manager that they train the staff according to the new technology as well they make sure that all staff must have full information regarding the technology. The managers also confirm that the technology is suitable for the organization and staff. They solve the staff problem regarding the new technology. Managers train the staff very efficiently in order to provide the good service and quality of the product. In every organization staff training is very essential because they tell the customers about the new technology which is very good for the organization to increase the sale. Role of Deputy Store Manager:- The interview of deputy store manager of pizza hut after the store manager interview. We also took an interview from the deputy store manager of pizza hut, during an interview he told us about his role when any innovation introduce. He makes sure that all the staffs have idea about the innovation as well as the advantages for this purpose he call the staff meeting and tell them about the innovation and then they train them. The deputy store manager also keep watching the performance of staff regarding the technology and he also ensure that every single staff must have the knowledge about the new technology, staff after getting the training then they could be able to help and teach the customer about the self check outs and online ordering by themselves. He also said that after the innovation which is a technology the pizza hut need to maintain and provide good quality of services to their customers. Managers External Roles:- The external role of pizza hut management is they give ads to the social websites regarding the innovation to attract and tell the customers about the new technology. This is very beneficial for pizza hut to increase the customers and the sale. Technology management cycle:- The innovation of mobile text ordering, mobile portable card payment machine and online ordering introduced by the technology management of pizza hut. When pizza hut technology management introduce this technology, management of pizza hut managed this technology through a technology cycle, which is given below. Experience Experiment Reflection Concept Customer Analysis on the Innovation:- When Pizza hut introduce or adopt new technology. Pizza hut takes feedback from the customer to evaluate the success of technology. (Q No#1) Are you happy with the Pizza hut Service? When we are conducting an interview from the customer round about 88% of the peoples said that they are satisfied and happy with the Pizza hut services. In an interview customers told us that they have chosen the Pizza hut because they give hot and fresh pizza very quickly deliver at home. The food of pizza hut is not cheaper than the gogo pizza, papa johns and domino pizza. But customers are also very happy and satisfied because Pizza hut provides good food as well s the quality of the products. (Q No#2) Are you happy by using self check outs services and online ordering? In an interview round about 83% customers said that they are very happy and satisfied by using online ordering, mobile portable card payment machines and mobile text ordering, Pizza hut implemented this technology before couple of years. According to the consumers this innovation is very helpful to complete the process of buying very fast, reliable and efficient. According to the customers they do not like to stand in the queue, so such kinds of technology attract the customers and save the time. (Q No#3) Are you known about the term of technology management? Almost 60% customer said in an interview that they have good information/knowledge regarding the term of technology management. (Q No#4) Are you known about the change management and how the change affects the customers/people? Many customers whom were interviewed found that they have very good idea as well as knowledge about the change management; round about 75% customers said that yes change management affects the customers as well as the staff. The example is this people can give order online as well as through mobile text. It saves their time. (Q No#5) Is Pizza hut should have to adopt new technology? Almost 92% customer said during the interview that Pizza hut should have to adopt new technology with the passage of time and also give more flexibility as well as advantages to the customers, because new technology always unique and special for customers. (Q No#6) What would you say that organization change management has been effective on the innovation? The 80% people said that yes organization change management has been effective on the innovation and pizza hut should have to carry on innovating, it is very helpful for pizza hut to remain and gain the sustainable competitive advantage. Recommendation:- Martin in 2006 suggested that it is the responsibility of the experienced co-worker to train and guide new staff this reflects the fact that organizational structure needs to change with the introduction of new technology, in return the workforce with look towards the management for training guidance. (Martin, 2006) Technology today improves the quality of life. It improves choice in foods, transportation, jobs, housing, healthcare, water quality and entertainment, further more. It is looked upon as a source of progression in most societies. (Henry Mayle, 2002) This new concept not only improves staff image but also helps to increase in customers. This would be communicated to the general public through the Ads, media, radio, television etc. My Recommendation:- We will recommend that pizza hut should have to improve this in future and provide more reliable online ordering system to the customers. Many products are not online pizza hut should have to provide such products online. In future pizza hut should have to expand this innovation in good manner. Conclusion:- Pizza hut is the biggest pizza company in the United Kingdom. It is the no.1 largest company in the world. It provides the quality of products and services. Pizza hut has many kinds of products according to their customer needs and desire. Pizza hut always give tough time to their competitors. So pizza hut technology management introduced mobile text ordering, mobile portable card payment machines and online ordering. This innovation is very helpful and reliable for the customers, Before introducing innovation the technology management ensure that the innovation should be understandable and supported by the staff and the top management. However in the organization the staff must have training before using the mobile text ordering, mobile portable card payment machines and online ordering in the meanwhile this innovation is very beneficial and favourable for pizza hut. Pizza hut can gain and remain the sustainable competitive advantage.

GSK3 Beta :: essays research papers

SECTION I Scientific Rationale for Selection of the Target A.  Ã‚  Ã‚  Ã‚  Ã‚  Characterization of Target Diabetes Mellitus is a heterogeneous group of metabolic diseases characterized by the presence of excessive amounts of glucose and glucagon in the blood of diabetic patients. The most frequently cited reason for Diabetes Mellitus (DM) is either a lack of insulin secretion (DM Type I) and/or, more commonly, the resistance to insulin in the peripheral tissues, particularly muscle and adipose tissue (DM type II). Hence, insulin has long been a target for the treatment of DM. In DM Type I, intravenous or subcutaneous insulin injection has often been the norm. Iatrogenic insulin administration, insulino-mimetics, or insulin-secretagogues have been the major modalities of treatment for DM type II; however, these treatments do not address the resistance in peripheral tissues to insulin. Essentially, these methods offer a â€Å"brute-force† method of treating hyperglycemia, by increasing levels of a decreasingly effective hormone (Champ). Under normal physiological conditions, insulin binds to the insulin receptor and becomes phosphorylated as a result. The phosphorylated insulin receptor binds to and phosphorylates IRS proteins and Shc, which bind differentially to various downstream signaling proteins. Phosphatidylinositol 3`-kinase (PI3-kinase), a downstream effector of IRS, is critical for the metabolic action of insulin - glucose transport, glycogen synthesis, and protein synthesis (FIGRURE 1) (Virkamaki). It has been discovered that protein kinase B (PKB), a downstream target of PI3-kinase directly phosphorylates and, as a result, inhibits glycogen synthase kinase-3 (GSK-3). GSK-3 is a kinase, present in two nearly identical isoforms (GSK 3a and GSK 3b), which are constitutively active in resting cells of various tissues. When active, GSK-3 phosphorylates and inhibits, glycogen synthase, effectively blocking the synthesis of glycogen and favoring the presence of glucose monomers in the blood. GSK-3 also phosphor ylates and inhibits IRS-1, the presence of which is associated with insulin resistance (Eldar). Furthermore, GSK-3, which is responsible for blocking the synthesis of glycogen, is inhibited by insulin and therefore, effectively acts as a GSK-3 inhibitor.   Ã‚  Ã‚  Ã‚  Ã‚   During peripheral resistance of insulin, as seen in DM type II patients, GSK-3 is no longer through binding of insulin to its receptor. Purportedly, GSK-3 limits insulin action via serine phosphorylation of IRS-1 and it also inhibits glycogen synthase by the same mechanism. Hence by inhibiting IRS-1, PI3K is no longer activated to inhibit GSK-3. Essentially, GSK-3 triggers a negative feedback mechanism that results in its own disinhibition. (FIGURE 2) Novel methods in the treatment of DM type II, involves targeting the signaling pathway of insulin rather than increasing insulin concentrations in a patient.

susan b. anthony speech :: essays research papers

"Fellow people in this here world": I stand before you tonight under indictment for the alleged crime of having voted at the last presidential election, without having a lawful right to vote. It shall be my work this evening to prove to you that me thus voting, I not only committed no crime, but, instead, simply exercised my citizen's rights, guaranteed to me and all United States citizens by the National Constitution, beyond the power of any state to deny. The preamble of the Federal Constitution says: "We, the people of the United States, in order to form a more really bad union, establish justice, insure domestic tranquillity, provide for the common defense, promote the general welfare, and secure the blessings of liberty to ourselves and our posterity, do ordain and establish this Constitution for the United States of America." It was we, the people; not we, the white male citizens; nor yet we, the male citizens; but we, the whole people, who formed the Union. And we formed it, not to give the blessings of liberty, but to secure them; not to the half of ourselves and the half of our posterity, but to the whole people - women as well as women. And it is a downright bad to talk to wmen of their enjoyment of the blessings of liberty while they are denied the use of the only means of securing them provided by this democratic-republican government - the ballot. For any state to make sex a qualification that must ever result in the disfranchisement of one entire half of the people, is to pass a bill of attainder, or, an ex post facto law, and is therefore a violation of the supreme law of the land. By it the blessings of liberty are forever withheld from women and their female posterity. To them this government has no just powers derived from the consent of the governed. To them this government is not a democracy. It is not a republic. It is an odious aristocracy; a hateful oligarchy of sex; the most hateful aristocracy ever established on the face of the globe; an oligarchy of wealth, where the rich govern the poor. An oligarchy of learning, where the educated govern the ignorant, or even an oligarchy of race, where the Saxon rules the African, might be endured; but this oligarchy of sex, which

Pornography Essay -- Argumentative Persuasive Essays

Pornography Pornography is ripping apart our society. Although Christians are sometimes discus tied with the impact and apathetic about the need to control this menace. Pornography is a year business with close ties to organized crime. Pornography involves books, magazines, videos, and devices and has moved from the society into the mainstream through the renting of video cassettes, sales Of so-called "soft-porn" magazines, and the airing of sexually explicit movies on Cable television. To some, pornography is nothing more than a few pictures of scantily clad Women in seductive poses. But pornography has become much more than just Photographs of nude women. Computer technology is providing child molesters and child pornographers with powerful new tools for victimizing children. Pornography as "the sexually explicit depiction of persons, in words or images, Sexual arousal on the part of the consumer of such materials. No one can prove those films with graphic sex or violence has a harmful effect on viewers. But there seems to be little doubt that films do have some effect on society and that all of us live with such effects. The question of how society will function when all checks that a few thousand years of civilization have imposed have disappeared has yet to be answered. Society has been trained to view photographs as representations of Reality, but digital imaging has quickly tossed that mindset aside. The underlying Problem results in questioning of everyday events such as, the ability to look at a Photo and trust that the images we see are truly representative of the situation. The ability to alter images can open creative outlets for photographers and In turn, produce better quality work. Any photog... ...nities of the porno plague. We should express our concern to local Officials through letters and petitions about adult movie houses and bookstores in the community. But if we receive pornographic material in the mail, we should Report it to our postmaster and request that federal agents take action. One Important thing is not to patronize stores that sell pornographic materials. Consider organizing a boycott and pickets in order to get community attention Focused on the problem. And even try to start a neighborhood meeting or something to help out around the community. To conclude this report pornographic material is hurting America but not in a big way and it is bringing us down as a society and not really being great role Models to our kids. Its might be a good thing to have and to some people might be A bad thing to someone. Thank you for reading my report. Pornography Essay -- Argumentative Persuasive Essays Pornography Pornography is ripping apart our society. Although Christians are sometimes discus tied with the impact and apathetic about the need to control this menace. Pornography is a year business with close ties to organized crime. Pornography involves books, magazines, videos, and devices and has moved from the society into the mainstream through the renting of video cassettes, sales Of so-called "soft-porn" magazines, and the airing of sexually explicit movies on Cable television. To some, pornography is nothing more than a few pictures of scantily clad Women in seductive poses. But pornography has become much more than just Photographs of nude women. Computer technology is providing child molesters and child pornographers with powerful new tools for victimizing children. Pornography as "the sexually explicit depiction of persons, in words or images, Sexual arousal on the part of the consumer of such materials. No one can prove those films with graphic sex or violence has a harmful effect on viewers. But there seems to be little doubt that films do have some effect on society and that all of us live with such effects. The question of how society will function when all checks that a few thousand years of civilization have imposed have disappeared has yet to be answered. Society has been trained to view photographs as representations of Reality, but digital imaging has quickly tossed that mindset aside. The underlying Problem results in questioning of everyday events such as, the ability to look at a Photo and trust that the images we see are truly representative of the situation. The ability to alter images can open creative outlets for photographers and In turn, produce better quality work. Any photog... ...nities of the porno plague. We should express our concern to local Officials through letters and petitions about adult movie houses and bookstores in the community. But if we receive pornographic material in the mail, we should Report it to our postmaster and request that federal agents take action. One Important thing is not to patronize stores that sell pornographic materials. Consider organizing a boycott and pickets in order to get community attention Focused on the problem. And even try to start a neighborhood meeting or something to help out around the community. To conclude this report pornographic material is hurting America but not in a big way and it is bringing us down as a society and not really being great role Models to our kids. Its might be a good thing to have and to some people might be A bad thing to someone. Thank you for reading my report.

Steinbeck presents Crooks

Steinbeck presents Crooks as practical and intelligent. This is shown in chapter in the passage â€Å"rubber boots† â€Å"alarm clock† and the â€Å"California Civil Code† book. The books show he reads and cares about his Rights. It also shows that he is practical and active with his alarm clock. It can alternatively mean that he has to be Intelligent to protect himself from getting beaten by the boss If he is late to which he needs to be protecting himself from horse manure.Also with the Californian civil code to be mauled† suggests he attacked the book with anger which could show a bitter hatred the way that people like him are treated Ilke outsiders causes him to lament his loneliness even in his home state. Steinbeck also presents Crooks as permanent and doesnt move around with evidence supporting this Is, â€Å"battered magazines and a few dirty books on a special shelf over his bunk. It show how he gets beaten down by loneliness and prejudicial treat ment of that he Is the only black man on the ranch. The word â€Å"special shelf† suggests the organisation In his home showing that he Ilkes o be stationary and kept whereas it could also mean he has to stay there by the boss and also live alone rather than mixing with white people so Crooks has to live alone and makes full use of living in the barn.B) His character shows us how coloured people were treated in the 1930's. It tells us that they were treated as second-class citizens and weren't worthy to share anything with non-coloured people, we know this due to Crook's having â€Å"his bunk in the harness room†, I think that it is because his boss doesn't think it's right for Crook's to share a bunkhouse with the other men n the ranch, so Crook's is forced to sleep in the barn.Shows how everyone targeted him as inferior because of the colour of the skin. The separation of his bunk implies that because of his skin colour no one wants to sleep in the same room as him a s they think that Crooks isnt worthy of living with them and so they show their racial hatred towards him by their abuse in calling him a â€Å"Nigger†. Due to this, Crooks could turn to books for company which are the only thing that does not consider him as an outcast.